Before joining FP2030, Twambilire was the Policy and Advocacy Officer for Amref Health Africa in Malawi. In this role, he led the planning, implementation, and monitoring of advocacy programs, including multi-country initiatives such as the Health Systems Advocacy Partnership and the Power to You(th) Program.  

As part of the Health Systems Advocacy Partnership, he played a pivotal role in advocating for a boost in budget allocation for Family Planning commodities in the 2020-2021 Malawi National Budget, securing an increase from MK176 Million to MK200 Million. In 2023, his involvement in the Power to You(th) Program facilitated Draft Amendments to the Child Care Protection and Justice Act, aiming to raise the age of a child from 16 to 18 years and to impose stricter penalties for sexual offenses against minors. Furthermore, he contributed to the development of amendments to the Gender Equality Act in Malawi, introducing a list of harmful practices to the act to eliminate ambiguity in legal proceedings. 

Twambilire also holds leadership positions, including Chairperson for the Amref Health Africa Multi-Country Policy and Advocacy Technical Working Group, fostering collaboration among 30 countries. As Country Coordinator for the Collaborative Advocacy Action Plan (CAAP), Twambilire led the establishment of Malawi’s Multi-Stakeholder Platform and Digital Advocacy Hub, aligning with global efforts to enhance women, children, and adolescent health. The Collaborative Advocacy Action Plan (CAAP) is a strategic framework from the Partnership for Maternal Newborn and Child Health (PMNCH)- part of WHO – aimed at mobilizing collective efforts to advocate for global improvements in reproductive, maternal, newborn, and child health. 

Twambilire is a proud father of two girls and one boy, and he enjoys practicing Kyokushin Karate in his free time.